eBook For {EPUB} Bioorganic And Enzymatic Catalysis 1st Edition

Preface vii

1 Enzymatic C─C Bond Formation by Aldol Reactions 1

Aldolases 1

Class I Aldolases 1

Bioorganic Class I Aldolase Reactions 3

Class II Aldolases 9

Class II Aldolase Mimics 11

References 13

2 Fatty Acid- and Polyketide-Synthases – Claisen-Type C─C Bond Formation 15

Biomimetic Decarboxylative C─C Bond Formation 20

References 23

3 Carbenium-Ion-Driven C─C Bond Formations – Terpenes 25

Enzyme-like Cyclisations Involving Carbenium Ions 30

References 41

4 Oxidations Catalysed by Heme Complexes 43

Monooxygenases 43

Cytochromes P 450 45

Synthetic P450 Enzyme Models 51

Chloroperoxidase (CPO) 57

Synthetic Enzyme Mimics of Chloroperoxidase (CPO) 60

NO Synthase (NOS) 63

References 67

5 Oxidations Catalysed by Non-heme Complexes and Other Co-factors 69

Methane Monooxygenase 69

Active Site Analogues of Methane Monooxygenase 71

Enzyme Mimics of Cu Monooxygenases 75

Flavin-dependent Monooxygenases 78

Enzyme Mimics of Baeyer–Villiger Monooxygenases 83

References 95

6 C–H Activation 97

References 110

7 Dioxygenases 111

Metal Complexes Displaying Dioxygenase-like Reactivity 127

References 134

8 Oxidoreductases 137

Cytochrome c Oxidase 148

References 150

9 Synthetic Systems That Mimic Certain Aspects of Oxidoreductases 153

References 173

Index 175